BRAIN MORPHOMETRY IN TOURETTES-SYNDROME - THE INFLUENCE OF COMORBID ATTENTION-DEFICIT HYPERACTIVITY DISORDER/

Three separate groups, using MRI, have reported basal ganglia abnormal ities in Tourette's syndrome (TS). We found similar abnormalities in b oys with attention-deficit/hyperactivity disorder (ADHD). Because TS a nd ADHD are frequently comorbid, we contrasted ADHD boys with and with out TS along with control subjects. As expected, we found a significan t loss of the normal globus pallidus asymmetry in the patients, but pr esence or absence of TS did not differentiate the ADHD groups. We conc lude that accounting for ADHD comorbidity will be important in future TS morphometric studies.