PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING IN PATIENTS WITH FRONTAL-LOBE EPILEPSY

Citation
Pa. Garcia et al., PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING IN PATIENTS WITH FRONTAL-LOBE EPILEPSY, Annals of neurology, 35(2), 1994, pp. 217-221
Citations number
23
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
ISSN journal
03645134
Volume
35
Issue
2
Year of publication
1994
Pages
217 - 221
Database
ISI
SICI code
0364-5134(1994)35:2<217:PMSIIP>2.0.ZU;2-#
Abstract
Phosphorus magnetic resonance spectroscopic imaging has previously dem onstrated localized metabolic abnormalities within the epileptogenic r egion in patients with temporal lobe epilepsy, including alkalosis, in creased inorganic phosphate level, and decreased phosphomonoester leve ls. We studied 8 patients with frontal lobe epilepsy, finding interict al alkalosis in the epileptogenic region compared to the contralateral frontal lobe in all patients (7.10 +/- 0.05 vs 7.00 +/- 0.06, P < 0.0 01). Seven patients exhibited decreased phosphomonoester levels in the epileptogenic frontal lobe compared to the contralateral frontal lobe (16.0 +/- 6.0 vs 23.0 +/- 4.0, P < 0.01). In contrast to findings in temporal lobe epilepsy, inorganic phosphate level was not increased in the epileptogenic region. Based on values derived from normal control subjects, 5 patients had elevated pH in the seizure focus and 2 patie nts had decreased phosphomonoesters while none had abnormalities in th e contralateral frontal lobe. These data suggest that magnetic resonan ce spectroscopy will be useful in the presurgical evaluation of patien ts with frontal lobe epilepsy.