PURPOSE: To evaluate the effects of lossy image (noninvertible) compre
ssion on diagnostic accuracy of thoracic computed tomographic images.
MATERIALS AND METHODS: Sixty images from patients with mediastinal ade
nopathy and pulmonary nodules were compressed to six different levels
with tree-structured vector quantization. Three radiologists then used
the original and compressed images for diagnosis. Unlike many previou
s receiver operating characteristic-based studies that used confidence
rankings and binary detection tasks, this study examined the sensitiv
ity and predictive value positive scores from nonbinary detection task
s. RESULTS: At the 5% significance level, there was no statistically s
ignificant difference in diagnostic accuracy of image assessment at co
mpression rates of up to 9:1. CONCLUSION The techniques presented for
evaluation of image quality do not depend on the specific compression
algorithm and provide a useful approach to evaluation of the benefits
of any lossy image processing technique.