DETOXIFICATION OF CYCLOPHOSPHAMIDE BY HUMAN ALDEHYDE DEHYDROGENASE ISOZYMES

Authors
VONEITZEN U MEIERTACKMANN D AGARWAL DP GOEDDE HW
Citation
U. Voneitzen et al., DETOXIFICATION OF CYCLOPHOSPHAMIDE BY HUMAN ALDEHYDE DEHYDROGENASE ISOZYMES, Cancer letters, 76(1), 1994, pp. 45-49
Citations number
17
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
76
Issue
1
Year of publication
1994
Pages
45 - 49
Database
ISI
SICI code
0304-3835(1994)76:1<45:DOCBHA>2.0.ZU;2-5
Abstract
In in vitro studies, no turnover of aldophosphamide and mafosfamide wa s observed with the tumor-specific aldehyde dehydrogenase 3 isozyme (A LDH3) isolated from human stomach mucosa as well as from lung (A549) a nd pharynx (UMSCC2) carcinoma cell lines. Only the human liver cytosol ic ALDH preparation (ALDH1) showed any significant oxidation of aldoph osphamide and mafosfamide.