BLOOMS SYNDROME CELLS GM1492 LACK DETECTABLE P53 PROTEIN BUT EXHIBIT NORMAL G1 CELL-CYCLE ARREST AFTER UV IRRADIATION

Citation
T. Vanlaar et al., BLOOMS SYNDROME CELLS GM1492 LACK DETECTABLE P53 PROTEIN BUT EXHIBIT NORMAL G1 CELL-CYCLE ARREST AFTER UV IRRADIATION, Oncogene, 9(3), 1994, pp. 981-983
Citations number
21
Categorie Soggetti
Genetics & Heredity",Oncology
Journal title
ISSN journal
09509232
Volume
9
Issue
3
Year of publication
1994
Pages
981 - 983
Database
ISI
SICI code
0950-9232(1994)9:3<981:BSCGLD>2.0.ZU;2-B
Abstract
The tumor suppressor gene p53 is thought to be a key factor in the ons et of G1 cell-cycle arrest following DNA damage. However, here we desc ribe cells derived from a patient with Bloom's syndrome, lacking any d etectable p53 protein, that still shows a functional G1 cell-cycle che ckpoint after irradiation with UV-C. Comparison with cells from other Bloom's patients showed that the absence of p53 protein is not a speci fic characteristic of Bloom's syndrome.