T. Vanlaar et al., BLOOMS SYNDROME CELLS GM1492 LACK DETECTABLE P53 PROTEIN BUT EXHIBIT NORMAL G1 CELL-CYCLE ARREST AFTER UV IRRADIATION, Oncogene, 9(3), 1994, pp. 981-983
The tumor suppressor gene p53 is thought to be a key factor in the ons
et of G1 cell-cycle arrest following DNA damage. However, here we desc
ribe cells derived from a patient with Bloom's syndrome, lacking any d
etectable p53 protein, that still shows a functional G1 cell-cycle che
ckpoint after irradiation with UV-C. Comparison with cells from other
Bloom's patients showed that the absence of p53 protein is not a speci
fic characteristic of Bloom's syndrome.