GRANULOSA-CELL TUMOR OF THE OVARY - A STUDY OF 18 CASES

In a study of 18 patients diagnosed with ovarian granulosa cell tumor between 1961 and 1992, clinical and pathologic findings were evaluated . Of the 18 patients, 15 (83.3%) were diagnosed in Stage I and three ( 16.7%) in Stage III or IV. Six patients (33.3%) underwent conservative surgery and in 12 (66.7%) total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. At follow-up three patients (16.6 %) had died of disease, three, 16 and 288 months, respectively, after initial surgery. The actuarial 5-year survival rate for Stage I was 10 0%, while that for Stages Ill and IV combined was 33.3% (P < 0.05). It is concluded that for patients with Stage IA, unilateral oophorectomy seems to be adequate treatment and for those with more than Stage IA, surgery should include total abdominal hysterectomy and bilateral sal pingo-oophorectomy. Postoperative adjuvant chemotherapy is advocated f or patients in whom spread of tumor beyond the ovaries has occurred. ( C) 1994 Wiley-Liss, Inc.