ANALYSIS OF MULTIPLE PRIMARY CANCERS IN A SINGLE INSTITUTION

Records of 120 patients with two and 16 with three primary cancers wer e evaluated. There were 49 males and 71 females among the double prima ries with ages ranging from 27-102 years (average 68 years at the time of fist cancer). Of 35 breast cancer patients 16 new primaries develo ped in the opposite breast and other sites including four colon, three lung, and three endometrium. Of 20 colon cancer patients second prima ries occurred in 11 sites most commonly colon (four) and lung (three). The frequency of second primaries may be skewed by the fact that pati ents with lethal cancers did not live long enough to develop them. Thi s is borne out by the fact that 74 of the 120 patients were alive at t he time of the study, implying a highly favorable group of patients. T he interval between primaries was longer in females than males (P < 0. 05) and this difference disappeared when breast and endometrial cancer were eliminated. When age was evaluate as a factor younger patients a ppeared to have a longer interval between primaries (P = 0.24) and thi s became significant for breast patients under age 55 years (91 months vs. 36 months) (P < 0.05). The stage of the second breast primary bor e no relationship to the interval between primaries. (C) 1994 Wiley-Li ss, Inc.