A REVIEW OF THE COLLISION-INDUCED DISSOCIATIONS OF DEPROTONATED DIPEPTIDES AND TRIPEPTIDES - AN AID TO STRUCTURE DETERMINATION

The structures of underivatized di- and tripeptides may be determined from a consideration of the collision-induced dissociations of their [ M-H]- ions. There are three types of fragmentation, viz. (i) the backb one cleavage which provides sequencing information, (ii) alpha side-ch ain cleavage irrespective of the position of the amino acid residue, a nd (iii) cleavages which are characteristic of amino acid residues in specific positions, in particular the N- or C-terminal positions.