RICHTERS-SYNDROME ASSOCIATED WITH LOSS OF RESPONSE TO TRANSFORMING GROWTH-FACTOR-BETA

Authors
NOWELL PC MOORE JS FOX FE CAPOCASALE RJ KANT JA BESA EC
Citation
Pc. Nowell et al., RICHTERS-SYNDROME ASSOCIATED WITH LOSS OF RESPONSE TO TRANSFORMING GROWTH-FACTOR-BETA, Leukemia research, 18(2), 1994, pp. 85-89
Citations number
24
Categorie Soggetti
Oncology,Hematology
Journal title
Leukemia research → ACNP
ISSN journal
01452126
Volume
18
Issue
2
Year of publication
1994
Pages
85 - 89
Database
ISI
SICI code
0145-2126(1994)18:2<85:RAWLOR>2.0.ZU;2-U
Abstract
A patient with chronic lymphocytic leukemia developed a large cell lym phoma apparently derived from the same neoplastic B-cell clone (Richte r's syndrome). At the same time, mitogen-stimulated proliferation of t he patient's circulating leukemic B-cells was no longer inhibited by t he regulatory cytokine transforming growth factor-beta (TGF-beta), sug gesting that such loss of inhibition might be contributing to the clin ical and biological progression of the disease.