PERIPHERAL-BLOOD HAIRY-CELL LEUKEMIA-CELLS EXPRESS ONLY LOW-AFFINITY IL-2 RECEPTORS

Authors
BULGER K MURPHY J JANCKILA A NICHOLS J MCCAFFREY R
Citation
K. Bulger et al., PERIPHERAL-BLOOD HAIRY-CELL LEUKEMIA-CELLS EXPRESS ONLY LOW-AFFINITY IL-2 RECEPTORS, Leukemia research, 18(2), 1994, pp. 101-104
Citations number
13
Categorie Soggetti
Oncology,Hematology
Journal title
Leukemia research → ACNP
ISSN journal
01452126
Volume
18
Issue
2
Year of publication
1994
Pages
101 - 104
Database
ISI
SICI code
0145-2126(1994)18:2<101:PHLEOL>2.0.ZU;2-U
Abstract
Purified leukemia cells from three patients with hairy cell leukemia w ere studied for IL-2 receptor status. All samples expressed the p55IL- 2 receptor subunit. However, none demonstrated sensitivity to the IL-2 -diphtheria toxin conjugate, DAB(486)IL-2, which shows selective cytot oxicity for high affinity IL-2 receptor-bearing cells. In the one case studied with I-125-IL-2 binding, only low affinity IL-2 receptors wer e noted. These data suggest that hairy cell leukemia cells express onl y low affinity IL-2 receptors and are insensitive to DAB(486)IL-2.