Five cases of laboratory-acquired infection with Brucella melitensis a
re reported. This pathogen is highly contagious when handled in the la
boratory. Clinicians should alert technologists when brucellosis is su
spected so that specimens are handled under the most stringent safety
measures. Serological surveys and instructions of laboratory workers r
egarding the clinical diversity of the disease are helpful for early r
ecognition of secondary cases. On the other hand, clinicians should co
nsider brucellosis in medical laboratory workers,vith unexplained sign
s and symptoms.