IMMUNOHISTOCHEMICAL DETECTION OF PROLIFERATING TUMOR-CELLS IN CERVICAL-CANCER USING MONOCLONAL-ANTIBODY KI-67

Monoclonal antibody Ki-67 identifies cells in G1, S, G2, and M phases of the cell cycle. In this cytokinetic study, Ki-67 was used to charac terize tumor cells in human cervical cancer specimen. This immunohisto chemical study showed that Ki-67 staining gave a brown nuclear reactiv ity dispersed heterogeneously in a tumor cell population and correlate d well with the mitotic activities of tumor cells. The finding suggest ed that Ki-67 staining provides an easily countable index for the stud y of proliferating cell populations in cervical cancer.