AUGMENTATION IN CYTOTOXICITY OF LYMPH-NODE LYMPHOCYTES BY OK-432

Authors
TANAKA N GOTOH K KOBAYASHI G GOUCHI A ORITA K
Citation
N. Tanaka et al., AUGMENTATION IN CYTOTOXICITY OF LYMPH-NODE LYMPHOCYTES BY OK-432, International journal of immunopharmacology, 16(2), 1994, pp. 131-135
Citations number
18
Categorie Soggetti
Immunology,"Pharmacology & Pharmacy
Journal title
International journal of immunopharmacology → ACNP
ISSN journal
01920561
Volume
16
Issue
2
Year of publication
1994
Pages
131 - 135
Database
ISI
SICI code
0192-0561(1994)16:2<131:AICOLL>2.0.ZU;2-G
Abstract
It has been demonstrated that natural killer (NK) cell activity of lym phnode lymphocytes (LNL) is very low and hardly augmented by interfero n. In this study, OK-432 was injected into the gastric cancer mass thr ough endoscopy one week before the operation, through which NK activit y of LNL was significantly increased. A single cell assay could divide the OK-432-injected patients into two groups; responder and nonrespon der. In responders, the increased activity induced by OK-432 was found also in the distal lymphnodes.