CALCIUM-ANTAGONISTS AND THE CENTRAL-NERVO US-SYSTEM

The calcium antagonists (CA) which are at our disposal are a pharmacol ogical class potentially active on the calcium homeostasis at the cent ral nervous system level. Instead of reviewing the whole possibility o f therapeutical potential targets, the authors review the 3 main possi ble and up-to-date impacts of these compounds : cerebral vasoactivity, neurotransmission, cell death. The actual lack of good clinical trial s in those fields is stressed as well as the consequent necessity to s timulate the undertaking of such trials in humans in order to avoid to limit the use of GA in the only cardio-vascular spectrum.