RING-D MODIFICATIONS OF ELLIPTICINE .1. NEW ELLIPTICINE DERIVATIVES FROM 1-CYANO-6-METHYLELLIPTICINE

Authors
BOOGAARD AT PANDIT UK KOOMEN GJ
Citation
At. Boogaard et al., RING-D MODIFICATIONS OF ELLIPTICINE .1. NEW ELLIPTICINE DERIVATIVES FROM 1-CYANO-6-METHYLELLIPTICINE, Tetrahedron, 50(8), 1994, pp. 2551-2560
Citations number
53
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
8
Year of publication
1994
Pages
2551 - 2560
Database
ISI
SICI code
0040-4020(1994)50:8<2551:RMOE.N>2.0.ZU;2-F
Abstract
New ellipticine derivatives are synthesized by modification of the cya nogroup of 1-cyano-6-methyl-ellipticine. This resulted in the formatio n of 1-acetyl- and 1-acetamido-6-methylellipticine. Deprotonation of 1 -cyano-6-methylellipticine under the influence of a palladium catalyst leads to a new annelated ellipticine (9). From the derivatives obtain ed, 9 showed the highest cytostatic activity.