RAT SALIVARY-GLAND BLOOD-FLOW AND BLOOD-TO-TISSUE PARTITION-COEFFICIENTS FOLLOWING X-IRRADIATION

Authors
HIRAMATSU Y NAGLER RM FOX PC BAUM BJ
Citation
Y. Hiramatsu et al., RAT SALIVARY-GLAND BLOOD-FLOW AND BLOOD-TO-TISSUE PARTITION-COEFFICIENTS FOLLOWING X-IRRADIATION, Archives of oral biology, 39(1), 1994, pp. 77-80
Citations number
19
Categorie Soggetti
Dentistry,Oral Surgery & Medicine
Journal title
Archives of oral biology → ACNP
ISSN journal
00039969
Volume
39
Issue
1
Year of publication
1994
Pages
77 - 80
Database
ISI
SICI code
0003-9969(1994)39:1<77:RSBABP>2.0.ZU;2-J
Abstract
Effects of a single high dose of X-irradiation (15 Gy) to the head and neck region in adult male rats were examined. Three days after radiat ion, rats were infused with [C-14]-iodoantipyrine (IAP) via the femora l vein. Animals were killed at designated times thereafter and the thr ee major salivary glands removed. The uptake of IAP by these tissues w as analysed using a pharmacokinetic model. Radiation had relatively mo dest effects on all measured variables when compared with results from the non-irradiated control and pair-fed groups.