SIMULATION OF ARTERIAL DRUG CONCENTRATION AFTER INTRAVENOUS APPLICATION

The aim of this study was to develop a widely applicable model for cir culatory indicator dispersion which could describe the pharmacokinetic s of early drug distribution.The model assumes that the substance is i njected into the right atrium and measured in the aorta. The dilution curve results from the dispersion and recirculation of the indicator i n the body. The concentration time curve in the aorta, r, can be descr ibed as r = c0 + g r, where g is the transport function of the body a nd c0 is the concentration time course, which is measured for the firs t time in the aorta. If the body transport function is known, then the aortic dilution curve of a drug can be predicted for different elimin ation rates and injection times. The site of interest can be chosen ar bitrarily, i. e. the concentration of inflow into the kidney or any ot her organ can be described.