PREVENTION OF DIABETES IN THE NOD MOUSE - IMPLICATIONS FOR THERAPEUTIC INTERVENTION IN HUMAN-DISEASE

The prevention of insulin-dependent diabetes (IDD) in humans remains a n elusive goal, despite the broad spectrum of therapeutic intervention s that prevent the development of IDD in the non-obese diabetic (NOD) mouse. Can an animal model in which spontaneous autoimmune pathology i s interrupted so easily serve as an archetype for the design of clinic al trials aimed at the prevention of IDD in humans? In this article, M ark Bowmans Edward Leiter and Mark Atkinson review the intervention st rategies that prevent IDD in the NOD mouse and indicate why these stud ies may well be relevant to the prevention of IDD in humans.