INTERLEUKIN-1 RECEPTOR-TYPE-I MESSENGER-RNA IN MOUSE-BRAIN AS AFFECTED BY PERIPHERAL ADMINISTRATION OF BACTERIAL LIPOPOLYSACCHARIDE

Following administration of endotoxin in vivo, alterations of interleu kin-1 (IL-1) receptor binding have been reported. In order to assess i n vivo regulation of IL-1 receptor gene expression in brain, mRNA leve ls for IL-1 receptor type I were measured after peripheral administrat ion of bacterial lipopolysaccharide in mice. When 25 mu g of lipopolys accharide were administered intraperitoneally, IL-1 receptor type I mR NA in the brain was increased after 3 h. After 20 h, the level was dim inished. This result suggests that bacterial lipopolysaccharide affect s regulation of IL-1 receptor type I mRNA expression in mouse brain.