EFFECT OF HEPARIN ON HEMAGGLUTININ OF HERPES-SIMPLEX VIRUS TYPE-1

Authors
NODA M INABA Y SENO M KANAMOTO Y TOKUMOTO S
Citation
M. Noda et al., EFFECT OF HEPARIN ON HEMAGGLUTININ OF HERPES-SIMPLEX VIRUS TYPE-1, Microbiology and immunology, 37(12), 1993, pp. 979-981
Citations number
14
Categorie Soggetti
Microbiology,Immunology
Journal title
Microbiology and immunology → ACNP
ISSN journal
03855600
Volume
37
Issue
12
Year of publication
1993
Pages
979 - 981
Database
ISI
SICI code
0385-5600(1993)37:12<979:EOHOHO>2.0.ZU;2-6
Abstract
Heparin inhibited the hemagglutinin activity of herpes simplex virus ( HSV) type 1. The minimal inhibitory concentration of heparin required to inhibit 8 hemagglutination (HA) U of HSV ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the HA inhibitory fact or of heparin. On the other hand, mouse erythrocytes treated with hepa rinase had greatly reduced agglutinability by HSV. Virus-heparin compl ex formation was observed by sedimenting heparin with the virus partic les.