OMENTAL-MESENTERIC INFLAMMATORY PSEUDOTUMOR - CYTOGENETIC DEMONSTRATION OF GENETIC CHANGES AND MONOCLONALITY IN ONE TUMOR

Background. Extrapulmonary inflammatory pseudotumor (plasma cell granu loma) is an uncommon lesion in adults and children, and little is know n either of its etiology or clinical characteristics. However, it rema ins a significant source of morbidity to patients and confusion to cli nicians. Methods. Case reports are presented of three patients with in traabdominal inflammatory pseudotumor who recently underwent surgery. A review of the recent world literature is also presented. Clinical an d laboratory characteristics of omental-mesenteric inflammatory pseudo tumor are reviewed along with a discussion of its etiology. Results. C ytogenetic data from cells of one patient show a derivative chromosome evolved from a translocation between the long arm of chromosome 2 and the short arm of chromosome 9 [(2;9) (q1,3;p2,2)].. Conclusions. The lesion is monoclonal, and genetic changes may play a crucial role in t he development of this neoplasm. Omental-mesenteric inflammatory pseud otumor appears to represent a distinct clinicopathologic entity as a b enign neoplasm in children.