CALORIC RESTRICTION PROFOUNDLY INHIBITS LIVER-TUMOR FORMATION AFTER INITIATION BY 6-NITROCHRYSENE IN MALE-MICE

Authors
FU PP DOOLEY KL VONTUNGELN LS BUCCI T HART RW KADLUBAR FF
Citation
Pp. Fu et al., CALORIC RESTRICTION PROFOUNDLY INHIBITS LIVER-TUMOR FORMATION AFTER INITIATION BY 6-NITROCHRYSENE IN MALE-MICE, Carcinogenesis, 15(2), 1994, pp. 159-161
Citations number
27
Categorie Soggetti
Oncology
Journal title
Carcinogenesis → ACNP
ISSN journal
01433334
Volume
15
Issue
2
Year of publication
1994
Pages
159 - 161
Database
ISI
SICI code
0143-3334(1994)15:2<159:CRPILF>2.0.ZU;2-Z
Abstract
Caloric restriction (CR) inhibited strongly the incidence of chemicall y-induced tumors in the neonatal B6C3F(1) mouse tumorigenicity bioassa y, when begun 3 months after treatment with the potent carcinogen 6-ni trochrysene, These data indicate that CR can have a profound inhibitor y effect on tumor development even long after metabolic activation and DNA repair have occurred.