GM CSF AND EOSINOPHIL CHEMOTACTIC FACTORS IN AN ACUTE LYMPHOBLASTIC-LEUKEMIA PATIENT WITH EOSINOPHILIA

We describe a patient with common acute lymphoblastic leukemia associa ted with blood and cerebrospinal fluid (CSF) eosinophilia. Serum obtai ned at onset and conditioned medium prepared from T cells obtained at remission stimulated with interleukin-2 contained eosinophil colony st imulating activity (Eo-CSA), which was confirmed to be predominantly G M-CSF. Leukemic cell conditioned medium and serum obtained at remissio n contained no Eo-CSA. The CSF contained increased eosinophil chemotac tic activity, however, this factor was not identified.