TRILINEAGE RESPONSE IN SEVERE APLASTIC-ANEMIA FOLLOWING LONG-TERM THERAPY WITH RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR

We investigated the effects of long-term therapy with recombinant huma n granulocyte colony-stimulating factor (rhG-CSF) in a 69-year-old man with severe aplastic anemia (SAA). The patient was too old to receive a bone marrow transplantation, and high-dose methylprednisolone and a ntilymphocyte globulin were ineffective. We administered rhG-CSF in co mbination with metenolone acetate. Trilineage blood cell components we re recovered 6 months later. These findings suggest that long-term G-C SF therapy may be beneficial in patients with SAA who are not candidat es for bone marrow transplantation.