J. Kikuta et N. Kitamori, EFFECT OF MIXING TIME ON THE LUBRICATING PROPERTIES OF MAGNESIUM STEARATE AND THE FINAL CHARACTERISTICS OF THE COMPRESSED TABLETS, Drug development and industrial pharmacy, 20(3), 1994, pp. 343-355
The effect of mixing time on hardness, disintegration time and ejectio
n force in tabletting of magnesium stearate and lactose granules was s
tudied. The hardness of the tablets decreased with an increase in mixi
ng time of the blends, as previously reported. A semilogarithmic plot
of the hardness versus mixing time gave a straight line having a turni
ng point. At the early phase of mixing the hardness was decreasing wit
h a large first-order rate and then continued to decrease with another
small first-order rate. The change in disintegration time or ejection
force versus mixing time was basically the same as that in the hardne
ss. This type of plot was applicable to the mixing magnesium stearate
with not only granular but also powdered materials.