Hjgm. Derks et al., PHARMACOKINETIC MODELING OF POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDS)AND FURANS (PCDFS) IN COWS, Chemosphere, 28(4), 1994, pp. 711-715
A physiologically based pharmacokinetic (PB-PK) model for 2,3,7,8-TCDD
in cows is described. Uptake in tissues appears to be blood flow limi
ted except in adipose. Sensitive model parameters are fat tissue volum
e and bioavailability. The agreement-between predicted and experimenta
l data is fairly good.