PHARMACOKINETIC MODELING OF POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDS)AND FURANS (PCDFS) IN COWS

Authors
DERKS HJGM BERENDE PLM OLLING M EVERTS H LIEM AKD DEJONG APJM
Citation
Hjgm. Derks et al., PHARMACOKINETIC MODELING OF POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDS)AND FURANS (PCDFS) IN COWS, Chemosphere, 28(4), 1994, pp. 711-715
Citations number
14
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
28
Issue
4
Year of publication
1994
Pages
711 - 715
Database
ISI
SICI code
0045-6535(1994)28:4<711:PMOPD(>2.0.ZU;2-R
Abstract
A physiologically based pharmacokinetic (PB-PK) model for 2,3,7,8-TCDD in cows is described. Uptake in tissues appears to be blood flow limi ted except in adipose. Sensitive model parameters are fat tissue volum e and bioavailability. The agreement-between predicted and experimenta l data is fairly good.