PEROXIDATION OF HUMAN BLOOD LIPOPROTEINS INDUCED BY EXOGENOUS HYPOCHLORITE OR HYPOCHLORITE GENERATED IN THE SYSTEM OF MYELOPEROXIDASE PLUS H2O2 PLUS CL-
Om. Panasenko et al., PEROXIDATION OF HUMAN BLOOD LIPOPROTEINS INDUCED BY EXOGENOUS HYPOCHLORITE OR HYPOCHLORITE GENERATED IN THE SYSTEM OF MYELOPEROXIDASE PLUS H2O2 PLUS CL-, Free radical biology & medicine, 16(2), 1994, pp. 143-148
Oxidation of human plasma lipoprotein (LP) was studied in the presence
of exogenous hypochlorite anion (OCl-) or OCl- generated in the ''mye
loperoxidase + H2O2 + Cl-'' system. OCl- effectively initiates peroxid
ation of lipids extracted from LP and those within LP particles, as ca
n be judged from accumulation of secondary (thiobarbituric acid [TBA]
reactive) and final (Schiff bases) products of lipid peroxidation (LPO
) in LP after incubation with myeloperoxidase or exogenous OCl-. Very
low density and low density lipoproteins classified as atherogenic LP
are more sensitive to OCl--induced LPO than high density lipoproteins.
These data allow us to propose that OCl- secreted by activated neutro
phils and monocyte-macrophages can produce oxidative modification of L
P in vivo. The latter is known as a risk factor in the development of
atherosclerosis.