EXTENSIVE BONE-MARROW NECROSIS AND SICKLE -CELL DISEASE

Extensive bone marrow necrosis and sickle cell disease. Three cases of extensive bone marrow necrosis in patients with sickle cell disease a re reported. All three patients presented severe bone pains with sever e anaemia (haemoglobin value less than 5 g/dl) and high increased of L DH serum values (upper than 20 fold normal value). Bone marrow aspirat e and biopsy showed typical signs of necrosis. The extent of necrosis was evaluated by reticuloendothelial scan obtained with In-111 chlorid e. Treatment required transfusions of phenotyped red blood cell concen trates. Favourable outcome was observed in all patients.