We critically discuss the reliability of the discrete nonlinear Schrod
inger equation (DNSE) approach in the case of a dissipative two-site s
ystem. By using the Wigner pseudo-probability formalism we show that t
he nonlinear effects predicted by this effective picture are generally
incorrect except in the adiabatic limit with the two-site system much
faster than its own thermal bath. This is the adiabatic condition opp
osite to that usually adopted to derive the DNSE and a simple explanat
ion of this result is given by establishing a connection between the H
artree approximation and the DNSE. Theoretical arguments are provided
to evaluate the error associated to the Hartree approximation, so as t
o assess under which physical circumstances this key approximation is
reliable.