RENAL EFFECTS OF IMMERSION IN ESSENTIAL-HYPERTENSION

Plasma concentrations of atrial natriuretic factor (ANF) have been rep orted to be unchanged or increased in patients with essential hyperten sion. Head out of water immersion (HOI) in a thermoneutral bath induce s diuresis and natriuresis, an increase in plasma ANF, and reductions in plasma renin activity and aldosterone concentrations. HOI was used in this study to stimulate the secretion of ANF, and compare its relea se in patients with essential hypertension (EH) (n = 14) and normotens ive subjects (n = 13). Renal function changes induced by HOI were also monitored. HOI that lasted 2 h was compared with a control-seated per iod in each subject. Blood pressure was significantly reduced (P < .05 ) in normotensive controls from 112 +/- 3/74 +/- 2 to 100 +/- 3/61 +/- 2 mm Hg, and in patients with EH from 137 +/- 4/93 +/- 3 to 123 +/- 3 /78 +/- 2 mm Hg. Plasma levels of ANF increased significantly (P < .05 ) in both groups from 5.9 +/- 1.3 to 16.3 +/- 3 pmol/L in normotensive controls and from 6.0 +/- 0.9 to 13.2 +/- 2.5 pmol/L in patients with EH. Plasma cyclic guanosine monophosphate concentrations increased mo re (P < .05) in the patients with EH (3.9 +/- 0.4 to 6.1 +/- 0.5 nmol/ L) than in controls (3.4 +/- 0.3 to 4.8 +/- 0.4 nmol/L), whereas plasm a renin activity levels decreased in controls (2.29 +/- 0.58 to 1.63 /- 0.55 ng/mL/h) and to a greater degree in patients with EH (1.62 +/- 0.52 to 0.77 +/- 0.19 ng/mL/h, P < .05) by HOI. Natriuresis increased significantly (P < .05) in both groups and to a similar degree by abo ut 60%, and renal vascular resistances decreased by 15%; however, glom erular filtration rate and renal blood flow did not change. From these physiological experiments, we conclude that patients with essential h ypertension do not produce more ANF in response to volume expansion bu t are more sensitive to its effects on cyclic guanosine monophosphate production. This is suggestive of an abnormally low response of ANF se cretion to atrial stretch in essential hypertension.