Lm. Marshall et al., AEROSOL DEPOSITION IN CYSTIC-FIBROSIS USING AN AEROSOL CONSERVATION DEVICE AND A CONVENTIONAL JET NEBULIZER, Journal of paediatrics and child health, 30(1), 1994, pp. 65-67
The deposition of technetium radiolabelled aerosol within the lungs of
12 stable cystic fibrosis patients (mean age 12.7 years) was compared
using the Acorn nebulizer and mouthpiece alone, and the Acorn nebuliz
er attached to the Mizer Aerosol Conservation Device (MACD). The total
activity delivered to the patient using the MACD was 11.1% (+/- 7.8%
s.d.) of the initial dose. compared to 5.8% (+/- 4.2% s.d.) with the n
ebulizer and mouthpiece alone (P<0.05). With the MACD, 84% of the intr
apulmonary dose was delivered to the peripheral regions, compared to 7
6.5% with the nebulizer and mouthpiece (P<0.05). No significant correl
ation was found between aerosol deposition and pulmonary function. The
Mizer Aerosol Conservation Device significantly increases both total
intrapulmonary aerosol deposition and peripheral aerosol distribution.