VOGT-KOYANAGI-HARADA SYNDROME COMPLICATING ALLOGENEIC BONE-MARROW TRANSPLANTATION

Vogt-Koyanagi-Harada (VKH) syndrome is an uncommon acute ophthalmologi cal disorder, characterised by bilateral serous retinal detachment wit h diffuse choroiditis, in association with specific extra-ocular manif estations. We describe a patient with unequivocal VKH syndrome arising 49 days after matched unrelated donor bone marrow transplantation (BM T) performed as treatment for severe aplastic anaemia. The visual symp toms and retinal changes responded well to cortico-steroids. The haema tological relevance of VKH syndrome is to distinguish it from retiniti s due to cytomegalovirus, which requires different therapy and has a f ar worse visual prognosis.