OLFACTORY-EVOKED POTENTIALS - ASSESSMENT OF YOUNG AND ELDERLY, AND COMPARISON TO PSYCHOPHYSICAL THRESHOLD

Olfactory-evoked potentials (OEPs) were recorded monopolarly at the Fz , Cz and Pz electrode sites in young adults and elderly subjects with an amyl acetate stimulus presented olfactometrically. Psychophysical o dor thresholds for amyl acetate were determined using a two-alternativ e, forced-choice detection procedure. These demonstrated a decreased o dor detection sensitivity in the elderly relative to the young subject s. In accordance with the threshold findings, elderly subjects produce d significantly smaller N1 and P2 amplitudes, and a trend towards long er latencies than younger subjects. Moreover, odor threshold was found to correlate with amplitude magnitude. The OEP findings, which are di scussed in the context of previous OEP studies, offer promise as an ob jective, non-invasive measure of sensory function in both clinical and non-clinical settings.