E. Novelli et al., A MOLECULAR INVESTIGATION SUGGESTS NO RELATIONSHIP BETWEEN OBSESSIVE-COMPULSIVE DISORDER AND THE DOPAMINE D-2 RECEPTOR, Neuropsychobiology, 29(2), 1994, pp. 61-63
Some studies suggest a relationship between obsessive-compulsive disor
der (OCD) and Gilles de la Tourette's syndrome. The pathophysiology of
the latter may involve the dopamine system. We screened three importa
nt exons of the dopamine D-2 receptor (DRD2) gene for mutations in a g
roup of OCD patients with or without ties. No structural changes were
found, suggesting no relationship between DRD2 and OCD. Moreover, the
frequency of the polymorphism in exon 6 was different from that found
in schizophrenics.