COMPARISON OF PENAL FUNCTION PARAMETERS IN THE ASSESSMENT OF CISPLATIN-INDUCED NEPHROTOXICITY

The early renal function parameters (RFP), i.e. urinary alanine aminop eptidase (AAP), beta-galactosidase (beta GAL), N-acetyl-beta-D-glucosa minidase (NAG), retinol-binding protein (RBP), albumin (ALB), total pr otein (TP) and the conventional RFP plasma creatinine were assessed in 8 patients before and during treatment with the nephrotoxic antitumor agent cis-platin. Plasma creatinine increased during treatment with c is-platin. In all patients, acute tubular damage was revealed by early RFP. Albumin and total protein excretion patterns suggested alteratio ns in glomerular function. The cumulative change in RBP excretion was related to plasma creatinine concentrations following cis-platin admin istration. The present study demonstrates that urinary RBP is a valuab le parameter for the early assessment of cis-platin-induced nephrotoxi city.