Ol. Casal et al., STRUCTURAL FEATURES OF LPPG AND RELATED-COMPOUNDS ISOLATED FROM TRYPANOSOMA-CRUZI TRYPOMASTIGOTES, Brazilian journal of medical and biological research, 27(2), 1994, pp. 227-231
A hydrophobic fraction isolated from trypomastigotes of Trypanosoma cr
uzi is being characterized using immunological and chemical techniques
. The lipopeptidophosphoglycan (LPPG) was identified in this fraction
since it gave a positive reaction with anti-LPPG rabbit serum and had
similar structural features such as the presence of ceramide as the li
pid moiety, furanoic galactose, and a glycan moiety consistent with th
at obtained from an authentic sample of epimastigote LPPG, as judged b
y thin-layer chromatography. Furthermore,the hydrophobic fraction cont
ained other glycolipids with different structural features. The lipid
moiety of these compounds is alkylglycerol rather than a ceramide, the
carbohydrate chain appears to be less complex than that in LPPG and n
o reactivity was observed towards an anti-LPPG serum.