ROLE OF THE ADRENERGIC PATHWAYS OF THE LATERAL HYPOTHALAMUS ON WATER-INTAKE AND PRESSER RESPONSE INDUCED BY THE CHOLINERGIC ACTIVATION OF THE MEDIAL SEPTAL AREA IN RATS
Jc. Callera et al., ROLE OF THE ADRENERGIC PATHWAYS OF THE LATERAL HYPOTHALAMUS ON WATER-INTAKE AND PRESSER RESPONSE INDUCED BY THE CHOLINERGIC ACTIVATION OF THE MEDIAL SEPTAL AREA IN RATS, Neuroscience letters, 167(1-2), 1994, pp. 153-155
In the present experiments, we investigated a possible involvement of
noradrenergic receptors of the lateral hypothalamus (LH) in the water
intake and presser response induced by cholinergic stimulation of the
medial septal area (MSA) in rats. The cholinergic agonist carbachol (2
nmol) injected into the MSA induced water intake and presser response
. The injection of an alpha(2)-adrenergic agonist, clonidine (20 and 4
0 nmol), but not of an alpha(1)-adrenergic agonist, phenylephrine (80
and 160 nmol), into the LH inhibits the water intake induced by carbac
hol injected into the MSA. The injection of clonidine or phenylephrine
into the LH produced no change in the MAP increase induced by carbach
ol injected into the MSA. The present results suggest that adrenergic
pathways involving the LH are important for the water intake: but not
for the presser response, induced by cholinergic activation of the MSA
.