PYRAZOLO[4,3-C]QUINOLINES, SYNTHESIS AND SPECIFIC-INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING - NOTE-II

Authors
SAVINI L MASSARELLI P CORTI P PELLERANO C BRUNI G ROMEO MR
Citation
L. Savini et al., PYRAZOLO[4,3-C]QUINOLINES, SYNTHESIS AND SPECIFIC-INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING - NOTE-II, Il Farmaco, 48(12), 1993, pp. 1675-1686
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
12
Year of publication
1993
Pages
1675 - 1686
Database
ISI
SICI code
0014-827X(1993)48:12<1675:PSASOB>2.0.ZU;2-9
Abstract
Two new series od 2-arylpyrazolo[4,3-c]quinolin-3-ones (6,8-difluoro- and 7,9-dichloro-derivatives) have been synthesized and tested for the ir ability to displace [H-3]flunitrazepam from rat brain membranes. Se veral compounds possess comparable and sometimes higher affinity for c entral benzodiazepine receptors than that of diazepam. Some selected c ompounds were also tested in vivo in the anti-pentylenetetrazol test; some anticovulsant activity resulted for the 6,8-difluoroderivatives o nly.