LOCALIZATION OF THE TAMM-HORSFALL GLYCOPROTEIN (UROMODULIN) GENE TO CHROMOSOME 16P12.3-16P13.11

Authors
POOK MA JEREMIAH S SCHEINMAN SJ POVEY S THAKKER RV
Citation
Ma. Pook et al., LOCALIZATION OF THE TAMM-HORSFALL GLYCOPROTEIN (UROMODULIN) GENE TO CHROMOSOME 16P12.3-16P13.11, Annals of Human Genetics, 57, 1993, pp. 285-290
Citations number
30
Categorie Soggetti
Genetics & Heredity
Journal title
Annals of Human Genetics → ACNP
ISSN journal
00034800
Volume
57
Year of publication
1993
Part
4
Pages
285 - 290
Database
ISI
SICI code
0003-4800(1993)57:<285:LOTTG(>2.0.ZU;2-9
Abstract
Mapping studies using a panel of 22 rodent-human somatic cell hybrids have helped to localize the Tamm-Horsfall glycoprotein (uromodulin) ge ne (UMOD), which has previously been reported to map to 16p13.11, to t he region 16p12.3-qter. The combined results indicate that U;MOD is lo cated distal to D16S295 and proximal to D16S287 and in the region 16p1 2.3-16p13.11. Uromodulin is known to affect the formation of calcium-c ontaining kidney stones, and this localization of UMOD will help in st udies of families with autosomal forms of nephrolithiasis.