SYNTHETIC STUDIES ON APLYRONINE-A, A POTENT ANTITUMOR SUBSTANCE OF MURINE ORIGIN - STEREOCONTROLLED SYNTHESIS OF THE C21-C34 SEGMENT

Authors
KIGOSHI H OJIKA M SUENAGA K MUTOU T HIRANO J SAKAKURA A OGAWA T NISIWAKI M YAMADA K
Citation
H. Kigoshi et al., SYNTHETIC STUDIES ON APLYRONINE-A, A POTENT ANTITUMOR SUBSTANCE OF MURINE ORIGIN - STEREOCONTROLLED SYNTHESIS OF THE C21-C34 SEGMENT, Tetrahedron letters, 35(8), 1994, pp. 1247-1250
Citations number
3
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
8
Year of publication
1994
Pages
1247 - 1250
Database
ISI
SICI code
0040-4039(1994)35:8<1247:SSOAAP>2.0.ZU;2-R
Abstract
The C21-C34 segment 2 of aplyronine A (1), a potent antitumor substanc e of marine origin, was synthesized enantioselectively in 25 steps (17 % overall yield) from imide 11.