This article reviews and synthesizes the literature on family variable
s and interaction processes associated with child and adolescent depre
ssion. The review focuses on two principal streams of literature: fami
lies of depressed children and children of depressed parents. In regar
d to the families of depressed children, specific attention is paid to
familial psychopathology, demographic factors, negative life events,
and family environment. The section on children of depressed parents a
ddresses genetic contributions, maternal and paternal depression, and
children's resilience in the face of parental depression. This is foll
owed by a brief review of the literature on the influence of sibling r
elationships in the manifestation of childhood depression. The article
concludes with a discussion of the interaction between family environ
ment and childhood depression.