QUANTITATIVE PATHOLOGY OF THE INTRAEPITHELIAL LARYNGEAL NEOPLASIA

A clinical-histologic and morphometric study on 32 patients with preca ncerous laryngeal lesions was carried out. Two biopsies taken at diffe rent times-were studied, and the cases in which carcinoma developed we re compared with those cases in which it did not. The only clinical-hi stologic variable with prognostic value, related with evolution to car cinoma, was severe dysplasia. The Malignancy Grading System, which gro uped together 13 clinical-histologic variables, had both high sensitiv ity and high specificity. On the other hand, quantitative microscopy w as a more sensitive and,objective method. Through the relationship bet ween the parameters of orientation/nuclearity and Histometric Progress ion Index, we could separate those cases in which invasive carcinoma-d eveloped from those cases in which ii did not with a sensitivity of 10 0% and a specificity of 82%.