T. Iwasaki et al., DIABETIC SCLEREDEMA AND SCLERODERMA-LIKE CHANGES IN A PATIENT WITH MATURITY-ONSET TYPE DIABETES OF YOUNG-PEOPLE, Dermatology, 188(3), 1994, pp. 228-231
A 21-year-old housewife with maturity onset type diabetes of young peo
ple developed scleredema diabeticorum, scleroderma-like skin thickness
on forearms and dorsum of hands, digital sclerosis and cheiroarthropa
thy. She had diabetes mellitus since the age of 11 years. Her grandfat
her on the mother's side, her mother and 3 of 5 her mother's brothers
and sisters have diabetes mellitus. Blood glucose was 295 mg/dl. Urina
ry glucose was 5.3 g/day. Nail fold capillary microscopy revealed a pr
ogressive systemic sclerosis pattern. Histologically, hematoxylin and
eosin sections from back and forearm skin demonstrated broad collagen
bundles separated by widened clear spaces throughout the thickened der
mis.