Fa. Prada et al., DNA-SYNTHESIS IN THE EMBRYONIC CHICK LENS EPITHELIUM IS ARRESTED AFTER EXPERIMENTAL LENS ROTATION, Histology and histopathology, 9(1), 1994, pp. 45-48
Using autoradiographic technique, we have studied DNA synthesis in nor
mal embryonic chick lens epithelium and after experimental lens rotati
on. Analysis of the autoradiograms clearly demonstrates that when the
lens primordium was rotated 180 degrees, so that lens epithelium was p
laced facing the interior of the optic cup, the lens epithelial cells
completely stop DNA synthesis. This fact suggests that some retinal an
d vitreal factors are responsible for differentiation and replicative
capacity of the lens epithelial cells.