A MORPHOLOGIC VARIANT OF MAY-HEGGLIN ANOMALY IN A CHINESE GIRL

An 8 yr old Chinese girl was investigated for easy bruising and mild t hrombocytopenia. Platelet aggregation studies and coagulation tests we re found to be normal. The giant platelets and Dohle-like cytoplasmic inclusions in granulocytes confirmed the diagnosis of May-Hegglin anom aly. The father's granulocytes also had Dohle-like inclusions and one paternal aunt had a history of bleeding tendency. Review of literature showed that such Dohle-like inclusions had always been described morp hologically as crescentic or spindle-shaped. In this case, however, th e shape was roundish, oval or poorly defined. Ultrastructurally, the c lassic description was electron-dense long rods and needles orientatin g along the long axis of the ''spindle''. In this case, the only elect ron-dense particles were dot-like with a haphazard arrangement.