Gastroendoscopic surveys have shown that horses in race training have
a greater prevalence of gastric ulceration than sedentary horses. To d
etermine if exercise affects gastric endocrine function the following
experiment was performed. Four horses were fed total mixed ration of g
round corn and chopped hay at 2% of their body weight, divided into 2
equal portions, daily. Horses were fasted overnight, and serum gastrin
concentration was determined just before and 2 hours after feeding. T
he horses were then sprint trained on a high speed treadmill for 6 wee
ks. The response of serum gastrin to feeding was then repeated as befo
re. Serum gastrin increased following feeding both before and after tr
aining, however the postfeeding gastrin value was higher [p = 0.035] a
fter training (68.1 +/- 6.9 pg/ml {mean +/- 1 SEM}) than before (42.7
+/- 3.8 pg/ml). These data show that treadmill exercise has an effect
upon the gastric hormonal response to a meal in the horse. The relatio
nship of this finding to the development of gastric ulcer disease is u
nknown at present, but warrants further investigation.