The effects of preexercise hyperinsulinemia on exercising plasma gluco
se, plasma insulin, and metabolic responses were assessed during 50 mi
n cycling at 62% VO2max. Subjects were fed a 6% sucrose/glucose soluti
on (LCHO) or a 20% maltodextrin/glucose solution (HCHO) to induce chan
ges in plasma insulin. During exercise, subjects assessed perceived na
useousness arid lightheadedness. By the start of exercise, plasma gluc
ose and plasma insulin had increased. In the LCHO trial, plasma glucos
e values significantly decreased below the baseline value at 30 min of
exercise. However, by 40 min, exercise plasma glucose and insulin val
ues were similar to the baseline value. Exercise plasma glucose and in
sulin did not differ from baseline values in the HCHO trial. Ingestion
of LCHO or HCHO was not associated with nausea or lightheadedness. It
was concluded that the hyperinsulinemia induced by preexercise feedin
gs of CHO did not result in frank hypoglycemia or adversely affect sen
sory or physiological responses during 50 min of moderate-intensity cy
cling.