A nine-month-old girl with osteomyelitis related to BCG vaccination is
presented. The patient did not have any clinical evidence of immunode
ficiency. Her X-ray examination showed a lytic lesion of the right tib
ia and of the left ulna. Histopathological examination of biopsy mater
ial revealed a chronic granulomatous inflammatory reaction. She improv
ed with intermittent short course antituberculosis therapy.