Cr. Persson et al., IMMUNIZATION AGAINST PORPHYROMONAS-GINGIVALIS INHIBITS PROGRESSION OFEXPERIMENTAL PERIODONTITIS IN NONHUMAN-PRIMATES, Infection and immunity, 62(3), 1994, pp. 1026-1031
Periodontitis is a common infectious disease in which the attachment t
issues of the teeth and their alveolar bone housing are destroyed, res
ulting in tooth loss. The gram-negative anaerobic microorganism Porphy
romonas gingivalis has been closely linked to severe forms of the dise
ase. We show for the first time that immunization of the primate Macac
a fascicularis with killed P. gingivalis in Syntex Adjuvant Formulatio
n-M inhibits progression of periodontal tissue destruction.