ISOTYPE AND ANTIGEN-SPECIFICITY OF PERTUSSIS AGGLUTININS FOLLOWING WHOLE-CELL PERTUSSIS VACCINATION AND INFECTION WITH BORDETELLA-PERTUSSIS

Authors
MINK CM OBRIEN CH WASSILAK S DEFOREST A MEADE BD
Citation
Cm. Mink et al., ISOTYPE AND ANTIGEN-SPECIFICITY OF PERTUSSIS AGGLUTININS FOLLOWING WHOLE-CELL PERTUSSIS VACCINATION AND INFECTION WITH BORDETELLA-PERTUSSIS, Infection and immunity, 62(3), 1994, pp. 1118-1120
Citations number
16
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
3
Year of publication
1994
Pages
1118 - 1120
Database
ISI
SICI code
0019-9567(1994)62:3<1118:IAAOPA>2.0.ZU;2-W
Abstract
Elevated agglutinin titers have been shown to correlate with protectio n from disease following whole-cell pertussis vaccination, but the iso type and antigen specificity of human agglutinating antibodies is unkn own. In 13 immunoassays, immunoglobulin G antifimbria antibodies had t he strangest correlation with agglutinin titers following culture-prov en infection with Bordetella pertussis (R' = 0.79; P < 0.0001) and fol lowing whole-cell pertussis vaccination (R' = 0.87, P < 0.0001).